FUB-AKB48 belongs to the synthetic cannabinoids family, which is a very diverse group of research chemicals, featuring many distinct families. Indazole-based substances are one of the classes of cannabinoids most suitable for systematic research. Indazole-based substances are characterized by a strong affinity for cannabinoid receptors, and their highly reliable behavior under lab conditions.

FUB-AKB48 is one of the latest products of the indazole family to become available on research chemical websites, and is getting a lot of interest. This research chemical is closely related to APINACA and 5F-APINACA, but has some slight structural changes in the form of a 4-fluorobenzyl group, which is substituted in place of a pentyl chain. The molecule contains an adamantyl-carboxamide moiety, and resembles a well known cannabinoid JWH-018 (which acts as a dominant agonist of the peripheral CB2 receptors), but due to presence of fluorobenzyl group, FUB-AKB48 is expected to display significant impact on CB1 as well.


AKB48 (Item No. 11566) is a pentyl indazole with structural similarity to the synthetic cannabinoids (CBs) JWH 018 adamantyl carboxamide (Item No. 9001193) and STS-135 (Item No. 11564), which have been sold for recreational use.1 Generally, quinolones with adamantyl-carboxamide moieties display high affinity for the peripheral cannabinoid (CB2) receptor but greatly reduced affinity for the central cannabinoid (CB1) receptor.2 AKB48 N-(4-fluorobenzyl) analog is an AKB48 derivative in which the pentyl chain has been replaced with a 4-fluorobenzyl group in order to mimic a structural feature of the potent CB1 modulator AB-FUBINACA (Item No. 14039). The physiological properties of this compound are not known. This product is intended for research and forensic applications.

Summary sheet: 5F-AKB48
Molecular structure of 5F-AKB48
Chemical Nomenclature
Common names 5F-AKB48, 5F-APINACA
Substitutive name 5F-APINACA
Systematic name N-(Adamantan-1-yl)-1-(5-fluoropentyl)-1H-indazole-3-carboxamide
Routes of Administration
WARNING: Always start with lower doses due to differences between individual body weight, tolerance, metabolism, and personal sensitivity. See responsible use section.
Threshold 0.5 mg
Light 0.5 – 1 mg
Common 1 – 2 mg
Strong 2 – 4 mg
Heavy 4 mg +
Total 30 – 60 minutes
Onset 0 – 20 minutes
Peak 10 – 30 minutes
Offset 5 – 10 minutes
After effects 15 – 30 minutes
DISCLAIMER: PW’s dosage information is gathered from users and resources for educational purposes only. It is not a recommendation and should be verified with other sources for accuracy.

5F-AKB48 (also known as 5F-APINACA) is a synthetic designer cannabinoid that acts as a potent agonist for the CB1 and CB2 cannabinoid receptors. It produces subjective effects somewhat similar to that of cannabis with a short duration and an emphasis on intense physical sensations. Its metabolism has been described in the scientific literature. It was first identified in South Korea[6]and is available for sale as a grey area research chemical through online vendors.

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Additional information


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